AbstractPatients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and activation. Acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 patients hospitalized with severe COVID-19 (11 on supplemental oxygen; 8 on mechanical ventilation), 18 of whom had increasing oxygen requirements at baseline. Over…
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California Gov. Gavin Newsom has signed a bill into law that requires restaurant chains to declare major food allergens on their menus. The requirement goes into effect in 2026 and covers restaurants with 20 or more locations. The menus will have to disclose ingredients including milk, eggs, shellfish and tree nuts when the restaurant operators
3 min read IT'S NOT GETTING any warmer here in the Northeast, but that's to be expected. What we didn't expect, though, was one of our all-time favorite outfitters, Huckberry, to mark down a bunch of its best-selling jackets just in time for the changing of the leaves. We just covered Huckberry's larger fall sale