“A clinical trial with MMR in high-risk populations may provide a ‘low-risk–high-reward’ preventive measure in saving lives during this unprecedented COVID-19 pandemic,” they wrote. There’s no serious risk to giving the vaccine to most people and the approach might be especially effective for protecting health care workers, they said.
“If we’re wrong, well, at least people will have new antibodies to measles, mumps and rubella. So there’s no harm, no foul,” Fidel told CNN.
“We emphasize this is strictly a preventive measure against the worst inflammatory sequelae of COVID-19 for those exposed/infected and does not represent an antiviral therapy or vaccine against COVID-19 in any manner,” Fidel and Noverr added in their letter.
One theory about why children and teens have much lower rates of coronavirus infection is that they have more recently received vaccines, including MMR, than adults have, and have some of the residual extra immune benefits. Some countries are giving people booster shots of a tuberculosis vaccine for this reason, and some experts have proposed using polio vaccines for a similar purpose.
Some vaccine experts are dubious about the theory that children are less vulnerable to coronavirus because of recent vaccinations.
Dr. Peter Hotez, a pediatrics professor at the Baylor College of Medicine, said children could be less vulnerable because they have more recently been infected with some of the other coronaviruses that cause the common cold.
“This might stimulate local or systemic cross protecting immunity,” Hotez told CNN.
Or there’s another possibility. “A more likely explanation is the lower expression of the ACE2 receptor in the upper respiratory tracts of children,” said Dr. Paul Offit of the Children’s Hospital of Philadelphia. The ACE2 receptor is a molecular doorway that is used by the new coronavirus to get into cells.
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